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Sedating antihistamines mechanism of action

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No dose adaptation is necessary for elderly or renally (kidney) impaired patients. S., it is classified as category B in pregnancy, meaning animal reproduction studies have failed to demonstrate a risk to the fetus but no adequate and well-controlled studies in pregnant women have been conducted.

As a "non-sedating" antihistamine, loratadine causes less (but still significant, in some cases) sedation and psychomotor retardation than the older antihistamines because it penetrates the blood/brain barrier to a smaller extent.

H1-antihistamines have been used for more than fifty years in treating various allergic manifestations. H1-antihistamines which penetrate into brain elicit, by inhibiting stimulant effect of histamine, drowsiness.Depending on the dose, the drug can produce paradoxical effects, including CNS stimulation or depression.Most antihistamines exhibit some type of anticholinergic activity.This may be followed by postictal depression and cardiovascular/respiratory arrest.Other common overdose symptoms include dry mouth, fixed dilated pupils, flushing of the face, and pyrexia.Almost everyone has taken an antihistamine to treat hay fever, itching, to relieve nausea and vomiting, in tablets and syrups used to treat cough and cold symptoms, or as an aid to sleep.